MPD Online Resource

CURRENT CLINICAL TRIALS FOR THE MPDs
Content Managers: Ruben A. Mesa, MD; Srdan Verstovsek, MD; Ayalew Tefferi, MD

· Trials for Myelofibrosis

· Trials for Polcythemia Vera

· Trials for Essential Thrombocythemia

· Trials for other MPDs

· International MPD Centers

· National MPD Centers

MPD CENTERS PARTICIPATING:

1. Trials for Myelofibrosis
Type of MPD	Drug Name	Drug Class	How do you take it?	Company	Background Info/Eligibility (click for more info)	Sites/Contact Info
MF	Bortezomib	Proteosome Inhibitor	IV	Millenium	Bortezomib Trial	Mayo Clinic Rochester, MN mesa.ruben@mayo.edu Mayo Clinic Jacksonville, FL rivera.candido@mayo.edu MD Anderson Cancer Center sverstov@mdanderson.org
MF	Azacytadine	Hypo-methylating agent	SQ	Pharmion	Azacytadine Trial	Mayo Clinic Rochester mesa.ruben@mayo.edu
MF	CC-4047 +/- prednisone	Immuno-modulatory	Pills	Celgene	Pomalidomide I Trial	Many sites in the USA and International (Hit Link)
MF	INCB018424	JAK2 Inhibitor	Pills	Incyte	Incyte	Mayo Clinic Rochester (Now Open) pardanani.animesh @mayo.edu MD Anderson Cancer Center (Now open) sverstov@mdanderson.org
MF	CEP-701	JAK2/ FLT3 Inhibitor	Pills	Cephalon	CEP-701	MD Anderson Cancer Center sverstov@mdanderson.org
MF	XL019	JAK2 Inhibitor		Exelixis	XL019	MD Anderson Cancer Center (Now open) sverstov@mdanderson.org Mayo Clinic Rochester (Opening soon) pardanani.animesh@mayo.edu
MF	Sunitinib	Anti-angiogenic	Pills	NCI Sponsored	Sunitinib	MD Anderson Cancer Center sverstov@mdanderson.org
MF	GX15-070MS	Pro-apoptotic	IV	GeminX	GX15-070MS	MD Anderson Cancer Center sverstov@mdanderson.org
MF: Myelofibrosis, Primary myelofibrosis (post ET/PV myelofibrosis) IV: Intravenous SQ: Subcutaneous [ Back To Top ]

2. Trials for Polcythemia Vera
Type of MPD	Drug Name	Drug Class	How do you take it?	Company	Background Info/Eligibility (click for more info)	Sites/Contact Info
PV	Pegasys	Pegylated interferon	SQ	Roche	Pegasys	MD Anderson Cancer Center sverstov@mdanderson.org

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3. Trials for Essential Thrombocythemia
Type of MPD	Drug Name	Drug Class	How do you take it?	Company	Background Info/Eligibility (click for more info)	Sites/Contact Info
PV	Pegasys	Pegylated interferon	SQ	Roche	Pegasys	MD Anderson Cancer Center sverstov@mdanderson.org

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4. Trials for other MPDs
Type of MPD	Drug Name	Drug Class	How do you take it?	Company	Background Info/Eligibility (click for more info)	Sites/Contact Info
CMML SM	Bortezomib	Proteosome Inhibitor	IV	Millenium	Bortezomib Trial	Mayo Clinic Rochester mesa.ruben@mayo.edu MD Anderson Cancer Center sverstov@mdanderson.org
HES	Imatinib	Tyrosine Kinase Inhibitor	Pills	Novartis	Imatinib	MD Anderson Cancer Center sverstov@mdanderson.org
HES	Cladribine + Cytarabine	Purine Nucleoside Analog	IV		2-CDA/ARA-C	MD Anderson Cancer Center sverstov@mdanderson.org
SM	RAD001	MTOR inhibitor	Pills		RAD001	MD Anderson Cancer Center sverstov@mdanderson.org
HES: Hypereosinophilic syndrome CMML; Chronic myelomonocytic leukemia SM: Systemic mast cell disease [ Back To Top ]

For Questions Contact: Ian Sweet | Webmaster: Digital Attic, LLC.
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